This is the transporter dilemma, too. Disintegrating people kills them. Making a long range replicator spit out an exact duplicate with all their memories doesn't mean they've moved.
Your body replaces all of your cells over the course of 7 to 10 years. So every 7 or so years, you are literally no longer the same person that you were. What's the difference between that and expediting the process with a transporter?
No because you didn't disintegrate my brain. Being disintegrated is a catastrophic, fatal injury that destroys the body, not just an imperceptible change like naturally ageing by one second.
My son and I talked at length about this one, and we agree with Bones. You wouldn't get me to go through a transporter unless I was already going to die. If there's any sort of afterlife, or soul, then that's where the people who have been transported are, and everyone else is a facsimile of themselves.
As long as he still has original thought. Considering our bodies are pure mechanical, original thought is all there is distinguishing us as not artificial. At least that's what we're programmed to think.