It's weird. Animation wise nothing would make me think it is an anime, and the dialogue has so many unusual pauses that makes the delivery feel really clunky.
It's riffing on sci-fi anime filled with philosophical reflection and nonlinear storytelling, like Ghost In The Shell, Ergo Proxy, Evangelion.
Not saying it's as great as those or anything, but it's hard to tell if it will be good by the time the plot wraps up. The animation for the Space Beth fight in (I think?) Episode 2 was pretty bad, though.
I want in not knowing anything and I just assumed that it was supposed to mimic the tropes of those bad 1980s anime, which would be something Rick and Morty would absolutely do. This article suggests that none of it was intentional and it was supposed to be a "good" show. I'm not so sure but it makes a compelling argument.
For what it’s worth, Japanese humor is certainly different than American humor. But it sounds like this is so far off the source material that it’s just plain bad.