Indeed, it's a bit more complex setup, you won't be able to boot without initramfs. But in certain cases (e.g. encryption or partitions spanning multiple devices) it is very useful.
1Gb EFI, rest of the disk LUKS with a single BTRFS inside. Use BTRFS subvols to divide things up. Swap as a swap file on BTRFS (be sure to set it as no_cow).
I prefer a very small EFI partition mounted at /boot/efi, that way the kernels and initrds sit at /boot alongside the rest ot the files (though if you also want encryption you need to add your encryption keys to initrd so you don't have to enter the password twice)
And / is tmpfs, /home is tmpfs, /nix, /etc/nixos, /var/log, /home/$username/downloads, /home/$username/documents, and some other directories are ZFS subvolumes bind-mounted at boot. That's only an option for NixOS or Guix though, so don't worry about opt-in state on other distros.
Same, except I also keep /var on a separate partition (old FreeBSD habit), as the I/O characteristics of /var are usually very different from rest of /
Usually, I do the simplest thing: all the stuff goes on one big ext4 partition. I don't make a separate partition for /home. I'll make a swap partition if I can remember but I've forgotten to do that before and nothing bad happened. The bootloader goes on a fat32 /boot/efi on the same drive as whatever the Linux install is on. This way I can swap around the drive to different pcs if I have to or easily change/upgrade drives without having to reinstall all my stuff.
This strategy works for dual booting Windows also. I'll put the windows install all on its own separate drive so it won't try to erase grub during a disk check or something. That happened one time. Also, by putting Windows and Linux on separate drives you can use the bios to boot between Windows or Linux if you mess up one of the bootloaders.
I haven't had swap since I started using 32GB of ram and I've been fine. Might be worthwhile to use LVM for a more adjustable partitioning just in case. I made the mistake of making root 50G and I've been fighting with it for a while.
I think you're going to get a wide variety of responses here. It comes down to a lot of factors.
For me personally, I've been shifting everything I have to Btrfs, so I can tell you what I've done recently and why.
A big caveat is that many of my systems have multiple physical drives. This means I'm often setting things up based on the speed and capacity of those disks.
But, I do have one system with a single drive shared for booting, root, and home. It's set up like this:
A FAT32 partition for /boot. 512 MB.
A single Btrfs partition across the rest of the drive.
Btrfs subvolumes: @ mounted at /, @home mounted at /home. @snapshots mounted at /.snapshots.
I could go crazy with other subvols (e.g. for /var/log), but ultimately it is sufficient for me to be able to snapshot / and /home separately.
For some of my other systems, I'll have / and /home on different drives. In that case, each has their own @snapshots with their own mount point. I tend still to throw the EFI boot partition mounted at /boot on the same drive as /.
It's very easy to simply change /etc/fstab as needed and point to another snapshot, effectively rolling back the drive to some former point as necessary.
Fair, I've not had any issues but I'm sure they exist. One or the other is faster based on workload, too, so it's not really that one is objectively better all the time.
Depends on your system. Desktop have different requirements than servers.
On both at minimum, I'd keep /home and /var/log separate. Those usually see the most writes, are least controlled, and so long as they're separate partitions they can fill up accidentally and your system should still remain functional. /tmp and /var/tmp should usually be mounted separately, for similar reasons.
/boot usually keep separate because bootloaders don't always understand the every weird filesystem you might use elsewhere. It would also be the one unencrypted partition you need to boot off of.
On a server, /opt and /srv would usually be separate, usually separate volumes for each directory within those as well, depending how you want to isolate each application/data store location. You could just use quotas; but mounting separately would also allow you to specify different flags, i.e. noexec, nosuid for volumes that should only ever contain data.
/var/lib/docker and other stuff in /var/lib I usually like to keep on separate mounts. i.e. put /var/lib/mysql or other databases on a separate faster disk, use a different file system maybe, and again different mount options. In distant past, you'd mount /var/spool on a different filesystem with more inodes than usual.
Highly secure systems usually require /var/log/audit to be separate, and needs to have enough space guaranteed that it won't ever run out of space and lock the system out due to inability to audit log.
Bottom line is its differnet depending on your requiremtns, but splitting unnecessarily is a good way to waste space and nothing else. Separate only if you need it on a different type of device, different mount options, different size guarantees etc, don't do it for no reason.
Regarding /boot, it can be encrypted as long as your bootloader can decrypt it, for example GRUB can decrypt LUKS encrypted partitions (albeit somewhat slowly). And the only partition that really has to be unencrypted is UEFI system partition (ESP), where bootloaders are located.
Real hardware separate for a server partitions for: /home, /var, swap, sometimes /usr, sometimes /var/log/audit
Depends on deployment requirements, and if a system is expected to run after filling up audit.
Real hardware for a at home desktop: /var, swap, maybe /home, or just one partition for / and one for swap.
Cloud: all one partition, put swap in a file if it is needed.
Cloud images are easy to grow if it is just one partition. Cloud-init will handle that automatically with the right packages installed, no configuration needed. Swap partitions are unlikely to be the right size as they vary according to memory and memory varies according to instance/guest sizes. Swap makes auto growing root partition harder (cloud-init custom config injection required). Best practice is to size workload and instances to not need swap whenever possible.
I personally have a tiny fat32 EFI partition, a small ext4 root, and everything else allocated to LVM2. Then LVs for every large path, like /home, /var, etc. I leave most of the extents unallocated until I need more space.