The scientist who configured a small drone to target people with facial recognition and chase them at full speed warns we have no defenses against such weapons.
Jamming is useless if it's autonomous. And over the decade+ I've been in the multirotor business, every net gun I've seen was shot at small stationary targets or larger barely moving targets. You would never hit a fpv sized quad going 60+mph.
Shotgun, 12ga, birdshot, no choke. Maybe Federal Flight Control shells. Tough shot if it's moving laterally and more than 50' away (esp. with no choke!), but a pellet through the right place is going to knock it down, or mess the controls up enough that it's not functional anymore.
You definitely want something a bit longer than a trenchgun for this though.