As a reminder, the same (closed-source) user-space components for OpenGL / OpenCL / Vulkan / CUDA are used regardless of the NVIDIA kernel driver option with their official driver stack.
The good: CUDA is required for maximum performance and compatibility with machine learning (ML) frameworks and applications. It is a legitimate reason to choose Nvidia, and if you have an Nvidia card you will want to make sure you have CUDA acceleration working for any compatible ML workloads.
The bad: Getting CUDA to actually install and run correctly is a giant pain in the ass for anything but the absolute most basic use case. You will likely need to maintain multiple framework versions, because new ones are not backwards-compatible. You'll need to source custom versions of Python modules compiled against specific versions of CUDA, which opens a whole new circle of Dependency Hell. And you know how everyone and their dog publishes shit with Docker now? Yeah, have fun with that.
That said, AMD's equivalent (ROCm) is just as bad, and AMD is lagging about a full generation behind Nvidia in terms of ML performance.
The easy way is to just use OpenCL. But that's not going to give you the best performance, and it's not going to be compatible with everything out there.
Right, I'm well aware that that article is the reason why a bunch of people have been making the unsubstantiated claim that Nvidia has hired people to work on Nouveau.
Nvidia hired the former lead Nouveau maintainer and he contributed a bunch of patches a couple of months ago after they hired him. That was his first contribution since stepping down and I'm fairly certain it was his last because there's no way Phoronix would miss the opportunity to milk this some more if they could. He had said when stepping down that he was open to contributing every once in a while, so this wasn't very surprising either way. To be clear, it is not evidence that he or anyone else was hired by Nvidia to work on Nouveau. Otherwise, I'd like to ask what he's been doing since, because that was over three months ago.