PSA: Apple Maps used to suck badly but now it's way better than Google Maps.
YouTube is unmatched for some music content and a lot of other stuff.
You don't sound like a mindless consumer, unfortunately, that isn't most people.
Vancouver mushroom entrepreneur Dana Larsen discusses being raided by police and the future of psychedelics
There is ongoing debate over how acetaminophen works.... We still don't entirely know but anyone can buy it OTC and even take so much that it kills them. Mechanisms are important, but far from the only criteria we have for determining if a drug is "safe."
A pair of recent cat studies transforms our understanding of how cats think, feel and interact with humans
Scientists in Brazil, the world's second-biggest consumer of cocaine, have announced the development of an innovative new treatment for addiction to the drug and its powerful derivative crack: a vaccine.
Does Lemmy allow crossposting? Try /c/drugnerds
Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication [2023]
Exposure to cannabis in adolescence is associated with increased risk of psychiatric disorders. Here, in a mouse model of 16p11.2 duplication, the authors identified a role of microglial Cnr1 for mediating the adverse effect of THC exposure on mPFC maturation and social memory.
This is according to a few studies that have questionable methodologies, such as how they measure "creativity" but yeah, in general drugs only bring out what already exists in someone's personality. If you're a really creative person to begin with, drugs can shift your perspective, which can be useful. But it isn't magic smart people juice.
As the United States continues to grapple with a devastating opioid-involved overdose crisis, conservative policymakers have seized on a familiar ...
Not only does astronomical sonification expand access for the blind community, it gives scientists new perspective
I know a lot of people are new here but this kind of shit should be moderated better... Link to the study, not someone's blog
Randomized trial of ketamine masked by surgical anesthesia in patients with depression - Nature Mental Health [2023]
In this clinical trial, a single dose of intravenous ketamine delivered during surgical anesthesia had no greater effect than placebo in acutely reducing the severity of depressive symptoms in adults with major depressive disorder.
Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis [2023]
A limitation of this study is its post hoc, exploratory design; recommendations for further research are provided.
IDK if you're aware, but invading Mexico is increasingly becoming a serious strategy on the right. So arguing against it is relevant, even if it's totally bonkers to anyone using logic.
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats [2023]
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders. A less explored topic concerns the use of repeated low doses of psychedelics, at a dose that is well below the psychedelic dose used in psychedelic-as...
The program was about education. But it was also about surveillance.
A trendy idea among GOP candidates would fail, just as it did in Colombia.
Reducing the harms of xylazine: clinical approaches, research deficits, and public health context - Harm Reduction Journal [2023]
Objectives Xylazine has emerged as a consistent part of the unregulated drug supply in recent months. We discuss major domains of xylazine’s harm, current knowledge deficits, clinical and harm reduction strategies for minimizing harm, and xylazine’s public health and policy context. As an interdisci...
Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala - Neuropsychopharmacology [2023]
Psychedelics such as psilocybin show great promise for the treatment of depression and PTSD, but their long duration of action poses practical limitations for patient access. 4-OH-DiPT is a fast-acting and shorter-lasting derivative of psilocybin. Here we characterized the pharmacological profile of...
