Drug Nerds
- www.sciencealert.com Scientists Unveil World-First Experimental Cocaine Addiction Vaccine
Scientists in Brazil, the world's second-biggest consumer of cocaine, have announced the development of an innovative new treatment for addiction to the drug and its powerful derivative crack: a vaccine.
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Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication
www.nature.com Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication - Nature CommunicationsExposure to cannabis in adolescence is associated with increased risk of psychiatric disorders. Here, in a mouse model of 16p11.2 duplication, the authors identified a role of microglial Cnr1 for mediating the adverse effect of THC exposure on mPFC maturation and social memory.
- filtermag.org Stop Scapegoating Immigrants for the Fentanyl-Involved Overdose Crisis
As the United States continues to grapple with a devastating opioid-involved overdose crisis, conservative policymakers have seized on a familiar ...
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Randomized trial of ketamine masked by surgical anesthesia in patients with depression - Nature Mental Health
www.nature.com Randomized trial of ketamine masked by surgical anesthesia in patients with depression - Nature Mental HealthIn this clinical trial, a single dose of intravenous ketamine delivered during surgical anesthesia had no greater effect than placebo in acutely reducing the severity of depressive symptoms in adults with major depressive disorder.
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Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis
pubmed.ncbi.nlm.nih.gov Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis - PubMedA limitation of this study is its post hoc, exploratory design; recommendations for further research are provided.
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
www.nature.com Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats - Molecular PsychiatryPsilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders. A less explored topic concerns the use of repeated low doses of psychedelics, at a dose that is well below the psychedelic dose used in psychedelic-as...
- slate.com The Kids Who Snitched on Their Families Because DARE Told Them To
The program was about education. But it was also about surveillance.
- foreignpolicy.com The U.S. Military Can’t Solve the Fentanyl Crisis
A trendy idea among GOP candidates would fail, just as it did in Colombia.
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Reducing the harms of xylazine: clinical approaches, research deficits, and public health context - Harm Reduction Journal
harmreductionjournal.biomedcentral.com Reducing the harms of xylazine: clinical approaches, research deficits, and public health context - Harm Reduction JournalObjectives Xylazine has emerged as a consistent part of the unregulated drug supply in recent months. We discuss major domains of xylazine’s harm, current knowledge deficits, clinical and harm reduction strategies for minimizing harm, and xylazine’s public health and policy context. As an interdisci...
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Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala - Neuropsychopharmacology
www.nature.com Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala - NeuropsychopharmacologyPsychedelics such as psilocybin show great promise for the treatment of depression and PTSD, but their long duration of action poses practical limitations for patient access. 4-OH-DiPT is a fast-acting and shorter-lasting derivative of psilocybin. Here we characterized the pharmacological profile of...