> Experiments in tiny freshwater animals suggest that certain tumors manipulate their host’s body to increase the likelihood of being transmitted to the next generation.

> A planet may have been destroyed by a white dwarf at the center of a planetary nebula — the first time this has been seen. As described in our latest press release, this would explain a mysterious X-ray signal that astronomers have detected from the Helix Nebula for over 40 years. The Helix is a planetary nebula, a late-stage star like our Sun that has shed its outer layers leaving a small dim star at its center called a white dwarf.

> Using social robots is a promising approach for supporting senior citizens in the context of super-aging societies. The essential design factors for achieving socially acceptable robots include effective emotional expressions and cuteness. Past studies have reported the effectiveness of robot-initiated touching behaviors toward interacting partners on these two factors in the context of interaction with adults, although the effects of such touch behaviors on them are unknown in seniors. Therefore, in this study, we investigated the effects of robot-initiated touch behaviors on perceived emotions (valence and arousal) and the feeling of kawaii, a common Japanese adjective for expressing cute, lovely, or adorable. In experiments with Japanese participants (adults: 21–49, seniors: 65–79) using a baby-type robot, our results showed that the robot’s touch significantly increased the perceived valence regardless of the expressed emotions and the ages of the participants. Our results also showed that the robot’s touch was effective in adults in the context of arousal and the feeling of kawaii, but not in seniors. We discussed the differential effects of robot-initiated touch between adults and seniors by focusing on emotional processing in the latter. The findings of this study have implications for designing social robots that have the capability of physical interaction with seniors.

> Social animals, including both humans and mice, are highly motivated to engage in social interactions. Short-term social isolation promotes social behavior, but the neural circuits through which it does so remain incompletely understood. Here, we sought to identify neurons that promote social behavior in single-housed female mice, which exhibit increased rates of social investigation, social ultrasonic vocalizations (USVs), and mounting during same-sex interactions that follow a period of short-term (3 days) isolation. We first used immunostaining for the immediate early gene Fos to identify a population of neurons in the preoptic hypothalamus (POA) that increase their activity in single-housed females following same-sex interactions (POA_social neurons) but not in single-housed females that did not engage in social interactions. TRAP2-mediated chemogenetic silencing of POA_social neurons in single-housed females significantly attenuates the effects of short-term isolation on social investigation, USV production, and mounting. In contrast, caspase-mediated ablation of POA_social neurons in single-housed females robustly attenuates mounting but does not decrease social investigation or USV production. Optogenetic activation of POA_social neurons in group-housed females promotes social investigation and USV production but does not recapitulate the effects of short-term isolation on mounting. To understand whether a similar population of POA_social neurons promotes social behavior in single-housed males, we performed Fos immunostaining in single-housed males following either same-sex or opposite-sex social interactions. These experiments revealed a population of POA neurons that increase Fos expression in single-housed males following opposite-sex, but not same-sex, interactions. Chemogenetic silencing of POA_social neurons in single-housed males during interactions with females reduces mounting but does not affect social investigation or USV production. These experiments identify a population of hypothalamic neurons that promote social behavior following short-term isolation in a sex- and social context-dependent manner.

> ## Abstract > > Background: Antimicrobial resistance (AMR) and smoking of tobacco products are two of the most important threats to global human health. Both are associated with millions of deaths every year. Surprisingly, the immediate interactions between these two threats are yet poorly understood. > > Objectives: Here we aimed to elucidate the effect of toxic compounds from cigarette smoke, ashes, and filters on the spread of antibiotic resistance genes in human lung and environmental microbiomes. > > Methods: Conjugation experiments using donor and recipient strain pairs of either Pseudomonas putida or Escherichia coli and AMR-encoding plasmids were conducted under exposure to different concentrations of cigarette smoke condensate in lung sputum medium, and cigarette ash and filter leachate in environmental media. We further measured reactive oxygen species (ROS) production of the donor strain under exposure to the cigarette-derived compounds to explore if stress experienced by the bacteria could be one of the underlying mechanism of changes in plasmid transfer frequencies. Furthermore, used cigarette filters were submerged in a wastewater stream for several weeks, and the colonizing communities were analyzed using high-throughput sequencing and high-throughput qPCR, and compared to unused control filters. > > Results: Exposure to cigarette smoke condensate at relevant concentrations resulted in more than 2-fold higher transfer rates of a multi-drug-resistance encoding plasmid in artificial lung sputum medium. This was associated with higher reactive oxygen species production as part of the bacterial stress response when exposed to cigarette-derived toxicants. Similar results were obtained for cigarette ash leachate in environmental medium. Further, used cigarette filters were colonized by different microbial communities compared to unused filters. These communities were significantly enriched with potential human pathogens and AMR. > > Discussion: The results of this study suggest that cigarette-derived compounds can indeed promote the spread of AMR within simulated human lung and environmental conditions. This study highlights that the consumption of cigarettes has not only direct but may also have indirect adverse effects on human health by promoting AMR.

> !First image captured by Firefly’s Blue Ghost lunar lander, taken shortly after confirmation of a successful landing at Mare Crisium on the Moon’s near side. This is the second lunar delivery of NASA science and tech instruments as part of the agency’s Commercial Lunar Payload Services initiative. > > Carrying a suite of NASA science and technology, Firefly Aerospace’s Blue Ghost Mission 1 successfully landed at 3:34 a.m. EST on Sunday near a volcanic feature called Mons Latreille within Mare Crisium, a more than 300-mile-wide basin located in the northeast quadrant of the Moon’s near side.

> Superconducting magnets inside a fusion reactor will experience conditions that aren’t seen anywhere on Earth. Materials scientists Susie Speller and Chris Grovenor are trying to predict how long these components can last in this extreme environment

> Tomato yellow leaf curl virus (TYLCV), a devastating pathogen of tomato crops, is vectored by the whitefly Bemisia tabaci, yet the mechanisms underlying TYLVC epidemics are poorly understood. We found that TYLCV triggers the up-regulation of two β-myrcene biosynthesis genes in tomato, leading to the attraction of nonviruliferous B. tabaci. We also identified BtMEDOR6 as a key whitefly olfactory receptor of β-myrcene involved in the distinct preference of B. tabaci MED for TYLCV-infected plants. TYLCV inhibits the expression of BtMEDOR6, canceling this preference and thereby facilitating TYLCV transmission to uninfected plants. Greenhouse experiments corroborated the role of β-myrcene in whitefly attraction. These findings reveal a sophisticated viral strategy whereby TYLCV modulates both host plant attractiveness and vector olfactory perception to enhance its spread.

> What measures can protect communities from measles outbreaks? > > Vaccination is the best way to protect individuals and communities from measles. It’s also the most effective way to curb an ongoing outbreak. > > High rates of vaccination are important because of a phenomenon called herd immunity. When people who are vaccinated do not get infected, it essentially stops the spread of the virus, thereby protecting those who are most susceptible to getting sick. When herd immunity wanes, the risk of infection rises for everyone – and especially for the most vulnerable, such as young children and people who are immunocompromised. > > Because measles is so contagious, estimates suggest that 95% of the population must be vaccinated to achieve herd immunity. Once vaccine coverage falls below that percentage, outbreaks are possible. > > Having robust public health systems also provides protection from outbreaks and limits their spread. Public health workers can detect cases before an outbreak occurs and take preventive steps. During a measles outbreak, they provide updates and information, administer vaccines, track cases and oversee quarantine for people who have been exposed and isolation for people who are contagious.

> The discovery of a biological "third state" between life and death suggests that our cells may possess a form of consciousness. Science is divided.

> An experimental treatment for an aggressive and lethal brain cancer has today been published in Nature Medicine, paving the way for a clinical trial to be conducted by researchers at The Brain Cancer Centre.

> Would you let a scientist implant a parasite in your brain to treat an illness? The idea of using a parasite as a medical tool might seem outlandish, but it also offers hope for conditions like Parkinsons and Alzheimer’s. Researchers have speculated that if a parasite could deliver drugs directly to the brain, it might help doctors treat these conditions. > > An international team of scientists is doing just that. They are using a single-celled parasite known as Toxoplasma gondii, which causes an infection called toxoplasmosis. The parasite naturally travels from the human gut to the central nervous system and delivers proteins to host cells. In the experiment, bioengineers hacked systems within the T. gondii’s cells that produce and release proteins outside the cell, called secretion systems.

> A new study shows that exposure to high temperatures adds up to 14 months to older adults' cellular age.

> The field’s failure to integrate medical services in the mid-20th century set the stage for its current troubles.

> As far as animals go, honey bees are world-class dancers. > > While not as deep and complex as a Super Bowl half-time show, the bees' moves, known as the “waggle" dance, convey very specific food foraging instructions to their nestmates. The direction the dancer moves explains to other bees which way to go, and the duration of the waggle dance, or the “run,” shows how far to go. Once other bees have been convinced to follow the directions, they are “recruited.” After receiving the instructions, these recruits leave the hive to find the food their sisters were so excited about.