Almost every distro can be operated with a mouse and keyboard. If you want to disable touch screen you have to look into that. Some articles might be there on arch wiki.
To echo others here, you really need to kill the driver. There are a couple of different kernel modules that might be involved, depending on exactly how your touch panel is connected to the rest of the system. Software that has no specific touch support will likely treat your renegade hardware as a mouse, rather than ignoring it.
Did you mean with touch support? They can all work without touch if you just don't use it.
Gnome works quite well with touch. I had to jump through some hoops to get KDE Plasma to work well enough on my Steam Deck. I have to use three different on screen keyboards (Maliit, Onboard and Steam's) depending on what I'm doing.
Seems like what you want is to disable the touch screen rather than a DE that specifically doesn't support it... Often times the touchscreen can be disabled in the BIOS/UEFI. But if that's not the case see: https://unix.stackexchange.com/a/531919
Another option would be to look into calibrating the touchscreen to stop the ghost inputs.
I usually don't use it, but everytime I get a chance to use GNOME with a touch screen I'm always impressed at how well it works. The onscreen keyboard could use some work though.
When I had my Pinephone I was really tempted to use Gnome as my DE. There were just some really small annoyances and it would have been perfect. Made me wish that Purism had thrown their weight directly at Gnome instead of making Phosh.