What are some downsides to immortality that most don't think of?

I'll start off with one, Being upset about a breakup that happened hundreds of years ago.

Edit 1:

Heath death of the universe, Death of the sun, etc, does not count. I feel like focusing on this is an overused point.

Edit 2:

Loneliness does not count. I feel like we all know immortality means you'll miss people and lose them.

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That old person feeling of no longer being with "it", and what's "it" now being strange and scary probably compounds over the centuries.
- And this is why elder vampires are so vengeful.
  
  I absolutely love the scene in "Interview with the Vampire" where Lestat is found hiding away in a room, distraught by all the creations of modern civilization.

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