If you want to follow artists and avoid all the right wing Nazis, 500 blocks is about the right number to keep your feed clear.
I personally block about 10,000 and comment vociferously on right wing threads, just so WatermElon Musk has to spend $$$ to present threads without my comments in the right-wing echo chamber. Block lists are fairly database-search intensive.
Well, I used to have a "real" account but now I only have the hobby account now. If he removes blocks, I might start up a bot army that replies to his every Xeet telling him what a stooge he is.