I've used it a lot, but unlike most of the others on this list, the commercial product (Photoshop) is so much better that I'm willing to shell out the monthly fee to use it over Gimp.
I’m not sure what field you’re in and photoshop certainly is the standard but Affinity has been great for my needs and is pay once if you’re looking to avoid SAAS
Only problem I have with it is the potential situation of (seemingly) uploading pictures which is bad for confidential stuff.
It may be local but I don't trust it that much.
Now for personal projects: Absolutely. I even used it once on my phone. Great page!