Yet, I don't see a direct relation between (trans) gender and sexuality. (I've seen a meme making fun of the similarity of the logos and packaging before, so I see the point).
I've seen this image pop up now and then for like 10+ years as a meme in the Linux community and never not once did I think this.
Obviously if that's a confirmed intention behind it, then it's not okay, but I think you're overthinking it, it's just how anime designs are, the characters often look agelessly young.
These look like pretty average anime characters to me and don't strike me as implying something problematic in the slightest.
Idk I'm an outside observer to weeb shit, but that's how I always interpreted it at least.
That is not ok either. Children adult sexual or romantic relationships are not ok because of the power dynamic. Both of legal rights and emotional and mental maturities.
If you're an adult, and you're interested in children's romance thats the same issue.
In fact, all content directed towards older audences featuring this kind of stuff, is directed to, and made by pedos.