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modeler @lemmy.world
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Since we have CRISPR and all the other cool stuff with gene splicing, might we be able to give ourselves gills one day?
  • In a way, your jaw is a gill arch, just built in a different way with some interesting diversions. After a couple of 100 million years, the changes do add up.

    If you really had to add in a gill, i have a plan, but I need to talk about one important evolutionary trick: duplication and divergence.

    A fairly common DNA copying error causes a section of a chromosome to be duplicated in the offpring. In most cases this is fatal or prevents children, but some duplications work out just fine.

    For instance mammals lost colour vision in the time of the dinosaurs - mammals were probably nocturnal. The loss was caused by losing genes for the yellow colour receptors in the eye. This is why dogs and cats see in something akin to black and white (they do see red and blue and all the yellows and greens are just shades of red and blue).

    But apes were lucky. An accident duplicated the existant red receptor and, over time, because there are now two genes, one gene was gradually selected for a higher and higher light frequency. This has become our green receptor and all apes see in red-green-blue colour.

    Duplication is not necessarily fatal because it just codes for something we already have. But once there are 2 genes, evolution can select away for different capabilities and we end up with something new.

    Ok, with that out the way let's plan!

    1. Add in a few new sections into the human body by adding some new hox genes. This would give us a significantly longer neck - probably fatal without medical support.
    2. Duplicate and diverge the genes used to trigger gill arch/neck and jaw development and modify the developmental genes that respond to them. This would preserve the development the upper neck as humans (to keep the jaw and ear) while allowing something else to happen lower down
    3. In the lower section work out a way to develop like our basal forms (something eel-like) and trigger this development with the modified genes from step 2.

    Step 1 might be possible today. Step 2 might be within current reach (but it would take incredible work to disentangle all the connected system in development and the working body. Step 3 is beyond current tech (as I understand).

  • Since we have CRISPR and all the other cool stuff with gene splicing, might we be able to give ourselves gills one day?
  • If you like this, this goes under the moniker 'evo/dev' - evolution of the 'development' of the organism. A lot of genes don't code for proteins that 'do' something in the body, like haemoglobin or fingernails - they code proteins that tell the body how to develop from a single cell. Many are active for a short window in development. Some are active in a single location, like at the thumb end of the limb bud, and tell the cells where to become a finger, thumb or palm bone. Some work across vastly different animal classes - the 'build an eye here' gene works in humans and flies and everything in-between.

  • Since we have CRISPR and all the other cool stuff with gene splicing, might we be able to give ourselves gills one day?
  • In short, we could, but the cost would be incredible.

    All vertebrates are animals that develop from a series of segments, with a vertebra at the core. In our time from eel-like fish, we've specialised these segments so, for example, we have ribs on the vertebra corresponding to the rib cage.

    To support arms and legs, specific vertebra have become highly specialised in the form of hips and shoulders.

    Gills are composed of a series of gill arches, one on each vertebra in the neck area. These structures have (in eels) a lot of blood vessels to carry the blood that needs reoxygenation.

    An interesting thing happened as the eel-like creatures differentiated, evolved jaws and ultimately ended up as mammals and humans: nature co-opted the specific vertebra that had these gill features and turned them into jaws and ears and a variety of other features in the head and neck. For example the tiny bones in your ear were once fish jawbones which were previously one (or more) gill arches.

    The stupendously complex anatomy in this area comes from all the short-term 'decisions' evolution took to make all the magnificent creatures that inhabit the earth.

    For example the nerve that connects the brain to the larynx (the recurrent laryngeal nerve) emerges from a vertebra high up in the neck, decends down under the aorta in the chest and then back up into the neck to the larynx. In the giraffe, the nerve is many meters long, even as it's direct path could be a few centimeters. The reason is that the heart used to be close to the gills in fish and sharks. As the heart moved in land animals, the nerve was caught in a loop around the critical aorta and it was 'pulled' along for the evolutionary ride.

    So, in order to turn your gills back on, you need to unprogram 450m years of evolution of the structures you call your head, face and neck.

    I'd recommend 'Your inner fish' by Shubin - it's a wonderful read and explains this in far more detail that I can manage.

  • Black Pepper Parmesan Pasta
  • Ahhh, cacio e pepe, the classic Roman pasta dish. But the cheese and pepper mix should end up creamy and sauce-like, not grainy like in the video.

    Here's Kenji with a demo that does produce a sauce, albeit cheating with butter. And here's a blender cheat from Babish.

  • 1274 - R-MastCam-Z - 110mm zoom
  • The stones in Machu Picchu are so perfectly fitted that you can't insert even a razor blade between them. Thousands of tiny monkey aliens swarming over the construction site with nuclear powered angle grinders polishing the rocks is the only reasonable explanation for this.

  • Spotted wood owl in Singapore

    Spotted an owl in the woods in Bishan Park in central Singapore early in the evening. Logically this makes it a spotted wood owl.

    Sorry for the low quality - it was at the limits of my Pixel 6 camera.

    2
    That is not vegan.
  • As an aside, oysters are not bivalves, they are brachiopods. Brachiopods do have a nervous system - some even have eyes.

    What's the difference and how do you tell a brachiopod from a bivalve? It's the plane of symmetry. In bivalves the plane of symmetry is where the shells (also known as valves) join. So bivalves have two identical shells. Whelks and razor shells are bivalves. Brachiopods also have two shells, but the shells are normally quite different. The oyster for example has one big concave shell and one small flat one on top. The big shell has a hole at the apex (just next to the hinge) and a root-like anchor grows from it to bind the brachiopod to the matrix on which it lives. Brachiopods have an axis of symmetry from this root/foot that vertically separates each shell into two mirrored parts.

  • Colorblindness check!
  • This is true for only red and green loght detecting proteins (opsins) - the blue opsin gene is on chromosome 7.

    The red and green detecting proteins have an interesting history in humans.

    Fish, amphibians, lizards and birds have 4 different opsins: for red, green, yellow and blue colours. And the blue opsin sees up into the ultra-violet. Most animals can see waaaay more colours in the world than we (or any mammal) can. So what happened that makes mammal vision so poor?

    It's thought that all mammals descend from one or a few species of nocturnal mammal that survived the catastrophe that wiped out the dinosaurs at the end of the Cretaceous. The colour detecting cells (the cones) need a lot of light compared to ones that see in black-and-white (the rods) and therefore nocturnal animals frequently lose cones in favour of the more sensitive rods for better night vision. The mammals that survived the Cretaceous extinction had also lost the green and yellow opsins while keeping red and blue - basically the two different ends of the light spectrum.

    Consequently today most mammals still have only 2 opsins so your cat or dog is red-green colourblind.

    Why do humans see green? Probably because our monkey forebears, who lived in trees and ate leaves, needed to distinguish red leaves and red fruit (visible to birds) from the green background.

    But how did we bring back the green opsin? A whole section of the X chromosome (where the red opsin is coded) got duplicated in a dna copying mistake and then there were two genes for red opsins. As there are different alleles (versions), they could be selected for independently and so one red opsin drifted up the spectrum to be specific for green. So our green opsin is a completely different gene to the green opsin in fish, birds, etc. This kind of evolution happens a lot which is why, for example, there are many families of similar hormones like testosterone and estrogen. And steroids too.

  • Justice Thomas Failed to Reveal More Private Flights, Senator Says
  • Someone has to decide whether it is or is not perjury. In this case it's the Senate and they need 2/3rd majority. So that basically means Supreme court judges (and presidents) are impossible to get rid of, even for perjury.

  • I rode a dinosaur, you IDIOT!
  • He's hiring a ghost writer because they are very cheap.

    When a person dies, they stop needing earthly rewards. And, because a lot of great authors and writers have died, there are a lot of candidate ghost writers, like Martin Amis, Truman Capote and Barbara Cartland. A good spiritualist can summon the right auteur from beyond this mortal coil for any compositional need you have!

  • People who had severe covid-19 show cognitive decline years later
  • Did you reply before even reading the summary:

    “What we found is that the average cognitive deficit was equivalent to 10 IQ points, based on what would be expected for their age, et cetera,” says Maxime Taquet at the University of Oxford.

    We are discussing progress over just 4 years and adjusting for age.