I’ve been on Vyvanse 50mg for a year and just added guanfacine a little over a month ago. My resting heart rate was averaging around 95 bpm on vyvanse alone, but adding guanfacine has lowered that down to about 65 bpm. Suffered from high blood pressure for years and was medicated for that too, but guanfacine has lowered that down to a reasonable range as well. It hasn’t done much for my ADHD so far, but I do feel physically better.