I've only really got experience with my own medications which is a combo of effexor and mirtazapine. For me when I drink alcohol, it feels like the effect is intensified. For example on one standard drink, i feel as drunk as if I had two standard drinks, if I drink two, I usually stop after 2 because I feel like I've had four and I'm ready to fall asleep. I've never experienced memory loss from alcohol but, I've never pushed myself past that limit, even before I went on antidepressiants. I think these drugs and combinations can be a very complex thing, and everyone can have different reactions.