What are some downsides to immortality that most don't think of?

I'll start off with one, Being upset about a breakup that happened hundreds of years ago.

Edit 1:

Heath death of the universe, Death of the sun, etc, does not count. I feel like focusing on this is an overused point.

Edit 2:

Loneliness does not count. I feel like we all know immortality means you'll miss people and lose them.

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Just depression in general. I don't want to live one lifetime, let alone never being able to die.

If you're immortal in a body that isn't broken then that might be a different story, but you'd still grow to love people only to have to lose them and go through that pain over and over.
- Highlander does a good job at highlighting this.

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