Chronic Fatigue Syndrome / Myalgic Encephalomyelitis @feddit.de Björn Tantau @swg-empire.de 5mo ago

Promising Treatment for Long Covid

www.mdpi.com Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2

Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 symptoms treated with HMG-Co-A reductase inhibitors (statin) plus angiotensin II type 1 receptor blockers (ARBs) for 6 weeks. Patients suffering from persistent symptoms (post-acute sequela...

They treated 16 patients with cholesterin and blood pressure medication and it showed a reduction of about 90 % in symptoms.

Here's an article in German about the study: https://www.hessenschau.de/gesellschaft/interview-marburger-post-covid-studie-zeigt-erstaunliche-erfolge-v1,cholesterin-long-covid-100.html

Can anyone gleen how bad the patients had it before treatment? I can't get further than the abstract in the full paper.

3 comments

Interviewer: What symptoms did the study participants have? There is a whole range of symptoms that can be attributed to post-Covid or post-vaccine.

Schieffer: The question of symptoms is a very critical one. We selected the patients very carefully. We assigned the symptoms of our many patients to certain clusters using an AI-based mathematical algorithm. Based on this, we selected the patients and assigned them to this therapy.

Schieffer: The group we examined here had developed an infection-related lipid metabolism disorder; this is the largest group of patients.

I have a lot of reasons to be skeptical of this study based on this interview. Either way, cholesterol and blood-pressure lowering meds are cheap, safe, and widely available, literally any doctor can prescribe those for you right now.
https://www.mdpi.com/1422-0067/25/8/4522#table_body_display_ijms-25-04522-t002

Edit: Sorry, link does not open the table. It's table nr. 2.
I don't know where this claim of 90 % reduction in symptoms originated – the figures show an improvement of e.g. Bell 60 => Bell 80 for the Post Covid group, the other scales are similar. I'm not able to analyze all of the data at the moment, but at second glance this seems to be an effective treatment, changing the scores ~ 15–30 %. Far from 90 %. And the effect might be exclusive to Covid related problems.

Edit:

Bei bis zu 90 Prozent der Betroffenen milderten sich die Symptome wie Müdigkeit, Schwindel, Schlafstörungen oder Herzrasen ab oder verschwanden sogar ganz.

The responder rate was 90 %, not the reduction of symptoms.