Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences (Zeifman, et al, 2023)

Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). These challenging experiences contribute to hesitancy toward psychedelic-assisted psychotherapy among health care providers and patients. Co-use of 3,4-Me...