MDMA-Assisted Therapy
- news.lykospbc.com Lykos Therapeutics Announces FDA Acceptance and Priority Review of New Drug Application for MDMA-Assisted Therapy for PTSD
PDUFA date is August 9, 2024 If approved, this would be the first MDMA-assisted therapy and psychedelic-assisted therapy SAN JOSE, Calif., Feb. 9, 2024 /PRNewswire/ -- Lykos Therapeutics (formerly...
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Effects of MDMA-assisted therapy for PTSD on self-experience (2024)
journals.plos.org Effects of MDMA-assisted therapy for PTSD on self-experienceIntroduction There is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical trial of participants with severe PTSD (NCT03537...
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Retraction (MDMA , brain lesions and Meth) - 2003
The originally published report (1) presented results from multiple studies performed in our laboratory over a span of approximately 2 years demonstrating that a novel systemic dose regimen of what we believed was MDMA produced severe dopamine neurotoxicity in two species of nonhuman primates, in addition to the previously reported serotonin neurotoxicity (3–6). Subsequent to the publication of those findings, we were unable to extend the dopamine neurotoxicity to orally administered doses. Multiple subsequent attempts to reproduce the original findings with systemically administered doses of MDMA identical to those used in the original study were also unsuccessful, under a variety of laboratory conditions.
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Dr. Ben Sessa talks ketamine and MDMA as non-specific adjuncts to psychotherapy
vimeo.com Dr. Ben SessaMDMA & Ketamine as tools to treat mental health, an interview with Dr. Ben Sessa MBBS (MD) MRCPsych. Dr. Ben Sessa MBBS (MD) MRCPsych has specialist training…
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MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study (Wolfson, et al, 2020)
www.nature.com MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study - Scientific ReportsThe success of modern medicine creates a growing population of those suffering from life-threatening illnesses (LTI) who often experience anxiety, depression, and existential distress. We present a novel approach; investigating MDMA-assisted psychotherapy for the treatment of anxiety in people with ...
MDMA is under investigation as an adjunct to psychotherapy for various anxiety-related conditions. Compelling results from six Phase 2 studies led the FDA to issue a Breakthrough Therapy designation for MDMA-assisted psychotherapy for treatment of posttraumatic stress disorder (PTSD) in 201716. In the Phase 2 trials, participants who were given active-dose MDMA (75–125 mg) and psychotherapy experienced significantly greater reductions in PTSD symptoms when compared with participants given inactive placebo or low-dose MDMA (0–40 mg)17,18,19,20,21. MDMA-assisted psychotherapy also reduced symptoms of depression and improved sleep quality. A study of MDMA-assisted psychotherapy in autistic adults with social anxiety also found significantly greater improvement in Leibowitz Social Anxiety Scale (LSAS) Total scores in the MDMA group compared to the placebo group22.
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MDMA keeps severe stress at bay (Frood, 2012)
www.nature.com MDMA keeps severe stress at bay - NatureProlonged relief reported from drug-enhanced therapy sessions.
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Oxytocin-dependent reopening of a social reward learning critical period with MDMA (Nardou, et al, 2019)
www.nature.com Oxytocin-dependent reopening of a social reward learning critical period with MDMA - NatureA critical period for social reward learning in mice, which closes at maturity, can be reopened by MDMA-mediated upregulation of oxytocin-dependent plasticity.
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Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations (Molla, et al, 2023)
www.nature.com Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations - Scientific ReportsMDMA is a stimulant-like drug with distinctive empathogenic effects. Its pro-social effects, such as feelings of connectedness, may contribute to both its popularity as a recreational drug and its apparent value as an adjunct to psychotherapy. However, little is known about the behavioral processes ...
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Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences (Zeifman, et al, 2023)
www.nature.com Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences - Scientific ReportsPsilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). These challenging experiences contribute to hesitancy toward psychedelic-assisted psychotherapy among health care providers and patients. Co-use of 3,4-Me...
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MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial - (Mitchell, et al, 2023)
www.nature.com MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial - Nature MedicineResults from the phase 3 placebo-controlled MAPP2 trial show that MDMA-assisted therapy reduces post-traumatic stress disorder (PTSD) symptoms and functional impairment in a diverse population with moderate to severe PTSD.
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MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study - (Mitchell, et al, 2021)
www.nature.com MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study - Nature MedicineResults from a phase 3, double-blind, randomized, placebo-controlled trial demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder.
