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Biomolecular condensates mediate bending and scission of endosome membranes | Nature

www.nature.com Biomolecular condensates mediate bending and scission of endosome membranes | Nature

Multivesicular bodies are key endosomal compartments implicated in cellular quality control through their degradation of membrane-bound cargo proteins1–3. The ATP-consuming ESCRT protein machinery mediates the capture and engulfment of membrane-bound cargo proteins through invagination and scission ...

We propose that condensate-mediated scission represents a previously undescribed scission mechanism that depends on the physicomolecular properties of the condensate and is involved in a range of trafficking processes.

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