Why does incest result in birth defects?
Just to be well and truly fuckin clear. I am not now nor have I ever been nor will I ever be contemplating shagging a family member.
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Interestingly, some species (naked mole rats for one,) are fairly immune to the problem.
If you selectively inbreed for long enough, the deleterious alleles are weeded out by selection. This is true for strains of laboratory mice, but not for any royal families that I know about.