Culber would know from the beginning that Stamets would fail and give up, but be encouraging and supportive none-the-less. Then when it happened he would act shocked and just say, “It’s okay, babe, you did your best.”
Right, the enhancements. He'd pick it up quick, but get bored and go back to solving medical anomalies, hanging in the holodeck with his boo, and moonlighting as an agent of Section 31.
Well, Seven would have explained their inferiority & proceeded to upload some Borg code (that may or not assimilate commentators at some point - but prob none of us would mind all that much).