Tried Jerboa and Liftoff for a few days but Connect is the first one that allowed me to have 2 accounts in 2 instances and do regular shit with them. Its the one that makes the most sense to me UI-wise, even though the way the comments are displayed is not the most pretty, but I think I can to play around with the settings to improve it.
I used Connect at first, and then recently got wefwef to try out as well. So far preferring wefwef, mainly for the layout. Something about the Connect controls on the left side of the screen was unintuitive/annoying for me, not sure why! But I'm keeping an eye on this thread because I don't have nearly enough experience yet to figure out what's best.