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If the premise intrigues me, then I'll usually be willing to play.
Art plays a strong role—but even if I love the art, I won't play if the premise sounds boring. I'll push through bad art for a good story. I find this weird because I am not willing to do the same for an anime or manga. This isn't exactly a harmful double standard, but I wonder why I have it. Off the top of my head I'll guess that I have less choice of otome to play because there are less otome out in English so I'll put up with more, while there are so many different anime and manga translated to English that I can afford to be choosy.
If it crosses some personal content lines I won't play—I am no good with gory images (descriptions are fine!). I also do not want to play a game where the MC faces sexism/misogyny, or anything that reads as too "serious real world issue in the media spotlight today".
If it has good self-insertion, tropes I love, an MC with a personality I want to see, or gameplay besides usual VN gameplay I'll be more likely to want to touch it.