If your home instance is federated with instances you don't want to see, you can use this script to remove all posts and comments from that instance without having to block communities individually.
Example:
Line 17: const blockedInstances = ["example.ml","lemmy.world"];
Edit the comma-seperated list on line 17 to the instances you wish to block. Add new ones inside quotes following a comma. Do not include https:// or trailing forward slashes in the instance text.
Yep I'm hoping we get more user-level control over the instances we see. This script is a naive client-side approach of just removing the HTML nodes of matching posts, but having it done on the server side would be ideal.