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Qubes OS
The virtual machine workflow has made me completely rethink how I use computers, and there's huge security benefits of compartmentalizing your digital life through Qubes. Qubes OS successfully compartmentalizes your VMs and brings them together under one unified desktop, so even though you have several VMs running, you can see all of them at once because you see their windows as if it was a regular Linux desktop.
There are some issues with it though, such as lack of 3D acceleration for gaming, and its rather picky hardware support. Along with needing hardware that supports Linux drivers, you need a crap ton of RAM (I'm running 20 GBs on my Thinkpad T450s) for all of the VMs you run at one time. It doesn't take as much CPU power as you'd think, though, as it uses Xen's PVH emulation, instead of full-blown virtual machines like you'd see with VirtualBox.
However, if you have the right hardware for it, and you don't mind dual-booting or using another machine for gaming, I urge you to give it a whirl.