The main thing I use these days is a modular setup, with mostly a lot of simple, single-function modules. Heavy on Doepfer and AI Synthesis.
I have a collection of analog mono synths and romplers, and a DX7. I usually avoid mixing computers and music, but lately I've been working on a microtonal controller and Surge XT has been great as something that's open source, supports MPE, and isn't too hard to set up.